| Month | Temp. (min) | Temp. (max) | Temp. (avg) | Precipitation |
| January | 18°F | 40°F | 27°F | 0.6" |
| February | 20°F | 43°F | 31°F | 1.1" |
| March | 34°F | 58°F | 44°F | 2.3" |
| April | 44°F | 68°F | 55°F | 4.1" |
| May | 54°F | 77°F | 65°F | 5.1" |
| June | 65°F | 87°F | 75°F | 5.2" |
| July | 68°F | 89°F | 78°F | 3.6" |
| August | 65°F | 87°F | 75°F | 4.1" |
| September | 56°F | 81°F | 68°F | 3.7" |
| October | 44°F | 69°F | 55°F | 3.6" |
| November | 32°F | 56°F | 43°F | 1.7" |
| December | 21°F | 41°F | 30°F | 1.6" |
| Index | Guilford | Missouri | National |
| Air quality index | 43 | 97 | 42 |
| Pollution index | 543,130 | 1,630,255 | 2,726,193 |
| Measurement | Total |
| Days measured | 365 |
| Days with good air quality | 283 |
| Days with moderate air quality | 82 |
| Days w/ poor A.Q. for sensitive groups | 0 |
| Days with unhealthy air quality | 0 |
| Pollutant | Total |
| Arsenic | 0.002% |
| Benzene | 0.020% |
| Carbon Tetrachloride | 0.002% |
| Lead | 0.003% |
| Mercury | 0.000% |
| City | Population | Air Quality Index | National Avg. |
| Arkoe, MO | 63 | 43 | 14.0% |
| Ravenwood, MO | 548 | 43 | 14.0% |
| Conception, MO | 291 | 43 | 14.0% |
| Stanberry, MO | 1,271 | 43 | 14.0% |
| Clyde, MO | 45 | 43 | 14.0% |
| Guilford, MO | 94 | 43 | 14.0% |
| City | Population | Air Quality Index | National Avg. |
| Georgetown, AR | 94 | 45 | 10.0% |
| The Rock, GA | 94 | 38 | 24.0% |
| Bennington, ID | 94 | 44 | 12.0% |
| Vernon, IL | 94 | 43 | 14.0% |
| Jennings, KS | 94 | 19 | 62.0% |
| Guilford, MO | 94 | 43 | 14.0% |
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