| Index | Charleston | Missouri | National |
| Average Test Scores | 21% | 44% | 48% |
| Student/Teacher ratio | 14:1 | 14:1 | 16:1 |
| Total public schools | 4 | 1,899 | 79,221 |
| Total private schools | 1 | 531 | 24,874 |
| Total post-secondary schools | n/a | 213 | 7,963 |
| Index | Charleston | Missouri | National |
| Completed 8th grade | 70.2% | 86.0% | 84.3% |
| Completed high school | 64.0% | 84.2% | 83.0% |
| Completed some college | 35.1% | 57.7% | 59.4% |
| Completed associate degree | 12.3% | 35.2% | 38.5% |
| Completed bachelors | 10.2% | 27.6% | 30.3% |
| Completed masters | 3.6% | 10.4% | 11.5% |
| Completed professional degree | 1.0% | 2.8% | 3.3% |
| Completed doctorate | 0.0% | 1.2% | 1.3% |
There are a total of 4 public schools, 1 private schools and n/a post-secondary schools in Charleston. Using the proficiency score averages, the average test scores for Charleston, MO schools is 21%. The average student to teacher ratio is 14:1. In Charleston, MO, an average of 70.2% of students have completed 8th grade and an average of 64.0% have completed high school.
| City | Population | Avg. Test Scores | National Avg. |
| Matthews, MO | 635 | 72% | 50.0% |
| Benton, MO | 885 | 42% | 12.2% |
| East Prairie, MO | 2,980 | 34% | 28.8% |
| Sikeston, MO | 16,664 | 34% | 30.2% |
| Mounds, IL | 916 | 13% | 74.0% |
| Charleston, MO | 5,478 | 21% | 57.3% |
| City | Population | Avg. Test Scores | National Avg. |
| Preston, ID | 5,477 | 46% | 4.7% |
| Somerdale, NJ | 5,479 | 35% | 28.1% |
| New Holland, PA | 5,479 | 62% | 28.1% |
| Cameron, TX | 5,476 | 40% | 17.4% |
| Chadron, NE | 5,482 | 57% | 19.5% |
| Charleston, MO | 5,478 | 21% | 57.3% |
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