| Month | Temp. (min) | Temp. (max) | Temp. (avg) | Precipitation |
| January | 18°F | 40°F | 27°F | 0.6" |
| February | 20°F | 43°F | 31°F | 1.1" |
| March | 34°F | 58°F | 44°F | 2.3" |
| April | 44°F | 68°F | 55°F | 4.1" |
| May | 54°F | 77°F | 65°F | 5.1" |
| June | 65°F | 87°F | 75°F | 5.2" |
| July | 68°F | 89°F | 78°F | 3.6" |
| August | 65°F | 87°F | 75°F | 4.1" |
| September | 56°F | 81°F | 68°F | 3.7" |
| October | 44°F | 69°F | 55°F | 3.6" |
| November | 32°F | 56°F | 43°F | 1.7" |
| December | 21°F | 41°F | 30°F | 1.6" |
| Index | Clarksdale | Missouri | National |
| Air quality index | 43 | 97 | 42 |
| Pollution index | 393,071 | 1,630,255 | 2,726,193 |
| Measurement | Total |
| Days measured | 365 |
| Days with good air quality | 283 |
| Days with moderate air quality | 82 |
| Days w/ poor A.Q. for sensitive groups | 0 |
| Days with unhealthy air quality | 0 |
| Pollutant | Total |
| Arsenic | 0.001% |
| Benzene | 0.010% |
| Carbon Tetrachloride | 0.001% |
| Lead | 0.000% |
| Mercury | 0.000% |
| City | Population | Air Quality Index | National Avg. |
| Agency, MO | 704 | 43 | 14.0% |
| Turney, MO | 206 | 43 | 14.0% |
| Easton, MO | 302 | 43 | 14.0% |
| Maysville, MO | 1,142 | 43 | 14.0% |
| St. Joseph, MO | 75,369 | 43 | 14.0% |
| Clarksdale, MO | 263 | 43 | 14.0% |
| City | Population | Air Quality Index | National Avg. |
| Cooper Landing, AK | 263 | 31 | 38.0% |
| Lemon Cove, CA | 263 | 66 | 32.0% |
| Hancock, IA | 263 | 40 | 20.0% |
| Randolph, IA | 263 | 40 | 20.0% |
| Stanley, ID | 263 | 36 | 28.0% |
| Clarksdale, MO | 263 | 43 | 14.0% |
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