| Statistic | Colmesneil | Texas | National |
| Population | 733 | 28,995,881 | 328,239,523 |
| Population density (sq mi) | 366 | 113 | 91 |
| Median age | 45.3 | 34.2 | 37.7 |
| Male/Female ratio | 1.1:1 | 1.0:1 | 1.0:1 |
| Married (15yrs & older) | 71% | 56% | 55% |
| Families w/ Kids under 18 | 36% | 48% | 43% |
| Speak English | 90% | 65% | 79% |
| Speak Spanish | 4% | 30% | 13% |
| Race | Colmesneil | Texas | National |
| White | 93.59% | 74.84% | 73.35% |
| Black | 0.00% | 11.95% | 12.63% |
| Asian | 2.05% | 4.36% | 5.22% |
| American Indian | 0.00% | 0.48% | 0.82% |
| Native Hawaiian | 0.00% | 0.08% | 0.18% |
| Mixed race | 2.05% | 2.50% | 3.06% |
| Other race | 2.32% | 5.79% | 4.75% |
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