| Index | De Soto | Illinois | National |
| Average Test Scores | 22% | 33% | 48% |
| Student/Teacher ratio | n/a | 18:1 | 16:1 |
| Total public schools | n/a | 3,938 | 79,221 |
| Total private schools | n/a | 1,438 | 24,874 |
| Total post-secondary schools | n/a | 306 | 7,963 |
| Index | De Soto | Illinois | National |
| Completed 8th grade | 88.3% | 86.2% | 84.3% |
| Completed high school | 83.6% | 84.7% | 83.0% |
| Completed some college | 58.0% | 61.8% | 59.4% |
| Completed associate degree | 33.5% | 40.7% | 38.5% |
| Completed bachelors | 23.2% | 32.9% | 30.3% |
| Completed masters | 10.2% | 12.7% | 11.5% |
| Completed professional degree | 2.3% | 3.4% | 3.3% |
| Completed doctorate | 2.0% | 1.2% | 1.3% |
There are a total of n/a public schools, n/a private schools and n/a post-secondary schools in De Soto. Using the proficiency score averages, the average test scores for De Soto, IL schools is 22%. The average student to teacher ratio is n/a. In De Soto, IL, an average of 88.3% of students have completed 8th grade and an average of 83.6% have completed high school.
| City | Population | Avg. Test Scores | National Avg. |
| Carterville, IL | 5,861 | 53% | 10.9% |
| Vergennes, IL | 238 | 37% | 22.9% |
| Herrin, IL | 12,806 | 36% | 24.7% |
| Carbondale, IL | 25,400 | 34% | 29.3% |
| Du Quoin, IL | 5,723 | 32% | 33.3% |
| De Soto, IL | 1,652 | 22% | 54.2% |
| City | Population | Avg. Test Scores | National Avg. |
| Middleburgh, NY | 1,652 | 52% | 8.3% |
| Bridgeport, OH | 1,652 | 63% | 30.6% |
| Berrien Springs, MI | 1,652 | 46% | 3.6% |
| Port Norris, NJ | 1,652 | 15% | 69.8% |
| Hildebran, NC | 1,652 | 42% | 12.5% |
| De Soto, IL | 1,652 | 22% | 54.2% |
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