| Statistic | De Soto | Wisconsin | National |
| Population | 514 | 5,822,434 | 328,239,523 |
| Population density (sq mi) | 421 | 108 | 91 |
| Median age | 42.6 | 39.1 | 37.7 |
| Male/Female ratio | 1.3:1 | 1.0:1 | 1.0:1 |
| Married (15yrs & older) | 38% | 57% | 55% |
| Families w/ Kids under 18 | 27% | 43% | 43% |
| Speak English | 99% | 91% | 79% |
| Speak Spanish | 0% | 5% | 13% |
| Race | De Soto | Wisconsin | National |
| White | 99.42% | 86.21% | 73.35% |
| Black | 0.00% | 6.29% | 12.63% |
| Asian | 0.00% | 2.57% | 5.22% |
| American Indian | 0.00% | 0.89% | 0.82% |
| Native Hawaiian | 0.00% | 0.02% | 0.18% |
| Mixed race | 0.00% | 2.19% | 3.06% |
| Other race | 0.58% | 1.83% | 4.75% |
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