| Month | Temp. (min) | Temp. (max) | Temp. (avg) | Precipitation |
| January | 32°F | 47°F | 38°F | 10.0" |
| February | 32°F | 49°F | 39°F | 6.9" |
| March | 41°F | 65°F | 51°F | 5.9" |
| April | 47°F | 69°F | 57°F | 4.6" |
| May | 58°F | 81°F | 69°F | 7.6" |
| June | 67°F | 88°F | 77°F | 5.8" |
| July | 69°F | 88°F | 77°F | 9.5" |
| August | 71°F | 92°F | 80°F | 9.0" |
| September | 62°F | 85°F | 72°F | 4.1" |
| October | 50°F | 73°F | 60°F | 11.0" |
| November | 39°F | 62°F | 49°F | 7.5" |
| December | 31°F | 47°F | 37°F | 8.3" |
| Index | Doniphan | Missouri | National |
| Air quality index | 26 | 97 | 42 |
| Pollution index | 346,319 | 1,630,255 | 2,726,193 |
| Measurement | Total |
| Days measured | 360 |
| Days with good air quality | 341 |
| Days with moderate air quality | 19 |
| Days w/ poor A.Q. for sensitive groups | 0 |
| Days with unhealthy air quality | 0 |
| Pollutant | Total |
| Arsenic | 0.000% |
| Benzene | 0.010% |
| Carbon Tetrachloride | 0.001% |
| Lead | 0.000% |
| Mercury | 0.000% |
| City | Population | Air Quality Index | National Avg. |
| Grandin, MO | 340 | 26 | 48.0% |
| Maynard, AR | 440 | 26 | 48.0% |
| Naylor, MO | 731 | 26 | 48.0% |
| Success, AR | 111 | 26 | 48.0% |
| Oxly, MO | 99 | 26 | 48.0% |
| Doniphan, MO | 2,467 | 26 | 48.0% |
| City | Population | Air Quality Index | National Avg. |
| Holiday Island, AR | 2,467 | 18 | 64.0% |
| Charlevoix, MI | 2,467 | 36 | 28.0% |
| Bentleyville, PA | 2,466 | 56 | 12.0% |
| Portage, PA | 2,466 | 39 | 22.0% |
| Fredonia, WI | 2,466 | 38 | 24.0% |
| Doniphan, MO | 2,467 | 26 | 48.0% |
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