| Index | East Prairie | Missouri | National |
| Average Test Scores | 34% | 44% | 48% |
| Student/Teacher ratio | 15:1 | 14:1 | 16:1 |
| Total public schools | 4 | 1,899 | 79,221 |
| Total private schools | n/a | 531 | 24,874 |
| Total post-secondary schools | n/a | 213 | 7,963 |
| Index | East Prairie | Missouri | National |
| Completed 8th grade | 64.6% | 86.0% | 84.3% |
| Completed high school | 54.4% | 84.2% | 83.0% |
| Completed some college | 29.5% | 57.7% | 59.4% |
| Completed associate degree | 10.2% | 35.2% | 38.5% |
| Completed bachelors | 8.3% | 27.6% | 30.3% |
| Completed masters | 2.7% | 10.4% | 11.5% |
| Completed professional degree | 0.5% | 2.8% | 3.3% |
| Completed doctorate | 0.0% | 1.2% | 1.3% |
There are a total of 4 public schools, n/a private schools and n/a post-secondary schools in East Prairie. Using the proficiency score averages, the average test scores for East Prairie, MO schools is 34%. The average student to teacher ratio is 15:1. In East Prairie, MO, an average of 64.6% of students have completed 8th grade and an average of 54.4% have completed high school.
| City | Population | Avg. Test Scores | National Avg. |
| Matthews, MO | 635 | 72% | 50.0% |
| New Madrid, MO | 2,863 | 37% | 22.9% |
| Sikeston, MO | 16,664 | 34% | 30.2% |
| Hickman, KY | 2,005 | 32% | 33.0% |
| Lilbourn, MO | 1,044 | 25% | 49.0% |
| East Prairie, MO | 2,980 | 34% | 28.8% |
| City | Population | Avg. Test Scores | National Avg. |
| Chevy Chase, MD | 2,979 | 69% | 43.0% |
| Delphi, IN | 2,979 | 50% | 3.5% |
| Lead, SD | 2,979 | 35% | 27.6% |
| Stanton, TX | 2,978 | 41% | 14.2% |
| Walsenburg, CO | 2,982 | 20% | 58.3% |
| East Prairie, MO | 2,980 | 34% | 28.8% |
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