| Statistic | Mesick | Michigan | National |
| Population | 381 | 9,986,857 | 328,239,523 |
| Population density (sq mi) | 287 | 178 | 91 |
| Median age | 44.1 | 39.5 | 37.7 |
| Male/Female ratio | 0.7:1 | 1.0:1 | 1.0:1 |
| Married (15yrs & older) | 49% | 55% | 55% |
| Families w/ Kids under 18 | 42% | 41% | 43% |
| Speak English | 98% | 91% | 79% |
| Speak Spanish | 2% | 3% | 13% |
| Race | Mesick | Michigan | National |
| White | 83.73% | 78.89% | 73.35% |
| Black | 0.00% | 13.89% | 12.63% |
| Asian | 0.52% | 2.79% | 5.22% |
| American Indian | 7.35% | 0.53% | 0.82% |
| Native Hawaiian | 0.52% | 0.03% | 0.18% |
| Mixed race | 6.82% | 2.74% | 3.06% |
| Other race | 1.05% | 1.12% | 4.75% |
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