| Statistic | Nespelem | Washington | National |
| Population | 215 | 7,614,893 | 328,239,523 |
| Population density (sq mi) | 1,108 | 117 | 91 |
| Median age | 33.3 | 37.6 | 37.7 |
| Male/Female ratio | 1.0:1 | 1.0:1 | 1.0:1 |
| Married (15yrs & older) | 43% | 56% | 55% |
| Families w/ Kids under 18 | 51% | 44% | 43% |
| Speak English | 96% | 81% | 79% |
| Speak Spanish | 0% | 8% | 13% |
| Race | Nespelem | Washington | National |
| White | 6.05% | 77.34% | 73.35% |
| Black | 0.00% | 3.63% | 12.63% |
| Asian | 0.00% | 7.80% | 5.22% |
| American Indian | 78.60% | 1.33% | 0.82% |
| Native Hawaiian | 0.00% | 0.63% | 0.18% |
| Mixed race | 13.95% | 5.34% | 3.06% |
| Other race | 1.40% | 3.92% | 4.75% |
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