| Statistic | New Melle | Missouri | National |
| Population | 428 | 6,137,428 | 328,239,523 |
| Population density (sq mi) | 254 | 90 | 91 |
| Median age | 53.7 | 38.3 | 37.7 |
| Male/Female ratio | 0.9:1 | 1.0:1 | 1.0:1 |
| Married (15yrs & older) | 84% | 57% | 55% |
| Families w/ Kids under 18 | 28% | 42% | 43% |
| Speak English | 98% | 94% | 79% |
| Speak Spanish | 1% | 3% | 13% |
| Race | New Melle | Missouri | National |
| White | 98.60% | 82.53% | 73.35% |
| Black | 0.00% | 11.58% | 12.63% |
| Asian | 0.70% | 1.78% | 5.22% |
| American Indian | 0.00% | 0.42% | 0.82% |
| Native Hawaiian | 0.00% | 0.11% | 0.18% |
| Mixed race | 0.70% | 2.44% | 3.06% |
| Other race | 0.00% | 1.13% | 4.75% |
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