| Month | Temp. (min) | Temp. (max) | Temp. (avg) | Precipitation |
| January | 39°F | 67°F | 53°F | 4.1" |
| February | 40°F | 70°F | 54°F | 5.0" |
| March | 46°F | 77°F | 61°F | 4.3" |
| April | 53°F | 83°F | 68°F | 4.9" |
| May | 61°F | 89°F | 75°F | 2.9" |
| June | 70°F | 94°F | 80°F | 7.6" |
| July | 72°F | 94°F | 81°F | 6.5" |
| August | 73°F | 94°F | 82°F | 8.3" |
| September | 69°F | 91°F | 79°F | 3.9" |
| October | 57°F | 84°F | 70°F | 2.7" |
| November | 46°F | 76°F | 60°F | 3.5" |
| December | 43°F | 70°F | 56°F | 5.7" |
| Index | Panacea | Florida | National |
| Air quality index | 40 | 35 | 42 |
| Pollution index | 1,265,590 | 7,570,785 | 2,726,193 |
| Measurement | Total |
| Days measured | 365 |
| Days with good air quality | 272 |
| Days with moderate air quality | 92 |
| Days w/ poor A.Q. for sensitive groups | 1 |
| Days with unhealthy air quality | 0 |
| Pollutant | Total |
| Arsenic | 0.001% |
| Benzene | 0.030% |
| Carbon Tetrachloride | 0.000% |
| Lead | 0.002% |
| Mercury | 0.000% |
| City | Population | Air Quality Index | National Avg. |
| Crawfordville, FL | 4,113 | 40 | 20.0% |
| St. Marks, FL | 340 | 40 | 20.0% |
| Sopchoppy, FL | 483 | 40 | 20.0% |
| Panacea, FL | 744 | 40 | 20.0% |
| City | Population | Air Quality Index | National Avg. |
| Clayhatchee, AL | 744 | 35 | 30.0% |
| Potomac, IL | 744 | 42 | 16.0% |
| New Harmony, IN | 744 | 45 | 10.0% |
| Parkdale, MI | 744 | 36 | 28.0% |
| Cedar Bluffs, NE | 744 | 40 | 20.0% |
| Panacea, FL | 744 | 40 | 20.0% |
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