| Month | Temp. (min) | Temp. (max) | Temp. (avg) | Precipitation |
| January | 35°F | 56°F | 45°F | 4.5" |
| February | 37°F | 59°F | 47°F | 3.0" |
| March | 45°F | 68°F | 56°F | 4.1" |
| April | 53°F | 77°F | 64°F | 4.1" |
| May | 61°F | 83°F | 71°F | 3.4" |
| June | 69°F | 90°F | 79°F | 3.7" |
| July | 71°F | 92°F | 80°F | 3.5" |
| August | 71°F | 91°F | 80°F | 5.7" |
| September | 66°F | 85°F | 74°F | 3.5" |
| October | 54°F | 76°F | 64°F | 3.8" |
| November | 43°F | 66°F | 54°F | 3.2" |
| December | 39°F | 59°F | 48°F | 5.1" |
| Index | Pickens | South Carolina | National |
| Air quality index | 46 | 37 | 42 |
| Pollution index | 770,308 | 3,620,438 | 2,726,193 |
| Measurement | Total |
| Days measured | 365 |
| Days with good air quality | 222 |
| Days with moderate air quality | 141 |
| Days w/ poor A.Q. for sensitive groups | 2 |
| Days with unhealthy air quality | 0 |
| Pollutant | Total |
| Arsenic | 0.010% |
| Benzene | 0.010% |
| Carbon Tetrachloride | 0.001% |
| Lead | 0.004% |
| Mercury | 0.000% |
| City | Population | Air Quality Index | National Avg. |
| Central, SC | 5,342 | 41 | 18.0% |
| Newry, SC | 98 | 41 | 18.0% |
| Seneca, SC | 8,424 | 41 | 18.0% |
| Salem, SC | 175 | 41 | 18.0% |
| Clemson, SC | 16,917 | 41 | 18.0% |
| Pickens, SC | 3,169 | 46 | 8.0% |
| City | Population | Air Quality Index | National Avg. |
| Cadiz, OH | 3,169 | 39 | 22.0% |
| Blue Ridge, VA | 3,169 | 38 | 24.0% |
| Pictou, NS | 3,169 | n/a | |
| Galena, IL | 3,168 | 29 | 42.0% |
| Homestead, PA | 3,168 | 56 | 12.0% |
| Pickens, SC | 3,169 | 46 | 8.0% |
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