| Month | Temp. (min) | Temp. (max) | Temp. (avg) | Precipitation |
| January | 26°F | 45°F | 34°F | 4.2" |
| February | 29°F | 50°F | 38°F | 4.0" |
| March | 38°F | 60°F | 48°F | 4.9" |
| April | 48°F | 73°F | 59°F | 5.8" |
| May | 55°F | 78°F | 65°F | 5.2" |
| June | 63°F | 84°F | 72°F | 5.1" |
| July | 66°F | 85°F | 75°F | 6.8" |
| August | 65°F | 84°F | 73°F | 5.6" |
| September | 59°F | 79°F | 68°F | 3.2" |
| October | 48°F | 70°F | 58°F | 3.7" |
| November | 38°F | 60°F | 48°F | 2.9" |
| December | 32°F | 50°F | 40°F | 5.2" |
| Index | Prestonsburg | Kentucky | National |
| Air quality index | 42 | 45 | 42 |
| Pollution index | 780,751 | 1,369,131 | 2,726,193 |
| Measurement | Total |
| Days measured | 365 |
| Days with good air quality | 299 |
| Days with moderate air quality | 66 |
| Days w/ poor A.Q. for sensitive groups | 0 |
| Days with unhealthy air quality | 0 |
| Pollutant | Total |
| Arsenic | 0.000% |
| Benzene | 0.010% |
| Carbon Tetrachloride | 0.002% |
| Lead | 0.000% |
| Mercury | 0.000% |
| City | Population | Air Quality Index | National Avg. |
| Betsy Layne, KY | 633 | 42 | 16.0% |
| Martin, KY | 351 | 42 | 16.0% |
| Coal Run Village, KY | 1,319 | 42 | 16.0% |
| Paintsville, KY | 4,032 | 42 | 16.0% |
| Allen, KY | 148 | 42 | 16.0% |
| Prestonsburg, KY | 3,537 | 42 | 16.0% |
| City | Population | Air Quality Index | National Avg. |
| Ballville, OH | 3,537 | 40 | 20.0% |
| Campo, CA | 3,536 | 64 | 28.0% |
| Riverwoods, IL | 3,536 | 55 | 10.0% |
| Frontenac, MO | 3,538 | 54 | 8.0% |
| Marienville, PA | 3,538 | 9 | 82.0% |
| Prestonsburg, KY | 3,537 | 42 | 16.0% |
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