| Statistic | San Luis | Colorado | National |
| Population | 665 | 5,758,736 | 328,239,523 |
| Population density (sq mi) | 1,173 | 56 | 91 |
| Median age | 48.9 | 36.4 | 37.7 |
| Male/Female ratio | 0.9:1 | 1.0:1 | 1.0:1 |
| Married (15yrs & older) | 55% | 56% | 55% |
| Families w/ Kids under 18 | 31% | 45% | 43% |
| Speak English | 41% | 83% | 79% |
| Speak Spanish | 59% | 12% | 13% |
| Race | San Luis | Colorado | National |
| White | 75.94% | 84.28% | 73.35% |
| Black | 0.00% | 4.09% | 12.63% |
| Asian | 0.00% | 2.94% | 5.22% |
| American Indian | 7.97% | 0.94% | 0.82% |
| Native Hawaiian | 0.00% | 0.14% | 0.18% |
| Mixed race | 4.66% | 3.43% | 3.06% |
| Other race | 11.43% | 4.18% | 4.75% |
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