| Statistic | Santee | Nebraska | National |
| Population | 357 | 1,934,408 | 328,239,523 |
| Population density (sq mi) | 633 | 25 | 91 |
| Median age | 24.9 | 36.2 | 37.7 |
| Male/Female ratio | 1.0:1 | 1.0:1 | 1.0:1 |
| Married (15yrs & older) | 38% | 59% | 55% |
| Families w/ Kids under 18 | 54% | 45% | 43% |
| Speak English | 90% | 89% | 79% |
| Speak Spanish | 3% | 7% | 13% |
| Race | Santee | Nebraska | National |
| White | 4.20% | 88.01% | 73.35% |
| Black | 0.28% | 4.70% | 12.63% |
| Asian | 0.84% | 2.12% | 5.22% |
| American Indian | 91.60% | 0.84% | 0.82% |
| Native Hawaiian | 0.56% | 0.07% | 0.18% |
| Mixed race | 1.96% | 2.32% | 3.06% |
| Other race | 0.56% | 1.95% | 4.75% |
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