| Statistic | Tupelo | Oklahoma | National |
| Population | 324 | 3,956,971 | 328,239,523 |
| Population density (sq mi) | 781 | 58 | 91 |
| Median age | 40.9 | 36.2 | 37.7 |
| Male/Female ratio | 1.0:1 | 1.0:1 | 1.0:1 |
| Married (15yrs & older) | 53% | 58% | 55% |
| Families w/ Kids under 18 | 48% | 44% | 43% |
| Speak English | 97% | 90% | 79% |
| Speak Spanish | 2% | 7% | 13% |
| Race | Tupelo | Oklahoma | National |
| White | 71.91% | 72.85% | 73.35% |
| Black | 0.00% | 7.26% | 12.63% |
| Asian | 0.00% | 2.00% | 5.22% |
| American Indian | 9.26% | 7.39% | 0.82% |
| Native Hawaiian | 0.00% | 0.13% | 0.18% |
| Mixed race | 15.74% | 7.73% | 3.06% |
| Other race | 3.09% | 2.64% | 4.75% |
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