| Index | Twain | California | National |
| Average Test Scores | n/a | 43% | 48% |
| Student/Teacher ratio | n/a | 20:1 | 16:1 |
| Total public schools | n/a | 8,308 | 79,221 |
| Total private schools | n/a | 3,438 | 24,874 |
| Total post-secondary schools | n/a | 1,085 | 7,963 |
| Index | Twain | California | National |
| Completed 8th grade | 76.9% | 81.1% | 84.3% |
| Completed high school | 76.9% | 79.8% | 83.0% |
| Completed some college | 76.9% | 61.5% | 59.4% |
| Completed associate degree | 0.0% | 39.8% | 38.5% |
| Completed bachelors | 0.0% | 32.0% | 30.3% |
| Completed masters | 0.0% | 11.9% | 11.5% |
| Completed professional degree | 0.0% | 3.9% | 3.3% |
| Completed doctorate | 0.0% | 1.6% | 1.3% |
There are a total of n/a public schools, n/a private schools and n/a post-secondary schools in Twain. Using the proficiency score averages, the average test scores for Twain, CA schools is n/a. The average student to teacher ratio is n/a. In Twain, CA, an average of 76.9% of students have completed 8th grade and an average of 76.9% have completed high school.
| City | Population | Avg. Test Scores | National Avg. |
| Quincy, CA | 1,706 | 42% | 13.3% |
| Greenville, CA | 785 | 24% | 50.5% |
| Twain, CA | 303 | n/a |
| City | Population | Avg. Test Scores | National Avg. |
| Halfway, OR | 303 | 57% | 18.8% |
| Caney, OK | 303 | 32% | 32.8% |
| Markleysburg, PA | 303 | 57% | 18.8% |
| Noble, LA | 303 | 60% | 24.0% |
| Milligan, NE | 303 | 50% | 4.2% |
| Twain, CA | 303 | n/a |
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